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Most people experience these side effects when they first start treatment or after each dose increase
In the context of varicocele, several clinical studies have reported elevated levels of pro-inflammatory cytokines such as IL-6 and TNF- in the systemic circulation (3, 15, 73)
Managing Side Effects During Your Starting Phase Mild nausea, reduced appetite, and occasional digestive changes are common when beginning tirzepatide, especially in the first one to two weeks
Confounding by obesity (which itself increases autoimmune risk)
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