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This conventional method, for some long peptides and peptide fragments with strong hydrophobicity, is easy to form beta-sheet secondary structure through intramolecular hydrogen bond during synthesis, thereby causing shrinkage of resin and resulting in coupling difficulty
It arrives in temperature-controlled packaging
We also thank Yoshihisa Fujino, MD, PhD, MPH (Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan) for valuable comments to this work
This unexpected development where FDA is reevaluating its position with respect to removing a product from the drug shortage list is a major backtrack from FDAs prior position and likely suggests that this issue (whether the product is or is not in short supply) will remain unresolved until perhaps the end of the year or even later
