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The cumulative incidence of NAION over 36 months was significantly higher in the semaglutide group (8.9%) compared to the non-GLP-1 RA group (1.8%)
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Receptor trafficking involves the internalisation of the active receptor: Ligand complex towards endocytic compartments, followed by its deactivation/dephosphorylation and recycling back to the cell membrane, leading to its re-sensitisation, or trafficking to lysosomal organelles for its degradation and final signal termination (McGlone et al., 2021)
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