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The most significant concern involves systemic infection (bacteremia or fungemia) in immunocompromised patients, though this remains rare with quality-controlled products
This failure is largely due to testing exclusively on cancer cell lines grown in liquid medium, a condition that predicts in vivo efficacy to anticancer drugs worse than cell culture in 3D gels [4, 5] and is far from adequately reflecting the therapeutic responsiveness of cancers within their native microenvironment [2, 3]
Toyama T, Yoshimura A, Hayashi T, Kobayashi N, Saito K, Tsuneizumi M, et al
Los protocolos de tratamiento suelen incluir sesiones semanales, durante 10 sesiones, pasando posteriormente a sesiones quincenales o mensuales como mantenimiento
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