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The Chang laboratory demonstrated that although TCF1-positive tumor-specific T cells were more likely to persist and proliferate in the tumor area after anti-PD-1 treatment, only a minority of the expanded TCR clones arose from TCF1-positive cells [166]
2021, doi: 10.1056/NEJMoa2032183
Additionally, the FDA recommends that these medications not be taken during pregnancy and be discontinued at least two months prior to pregnancy, because studies in rats, rabbits, and monkeys demonstrated that animals treated with these medications had higher rates of miscarriage, were born smaller, and were more likely to have birth defects
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