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As an additional control, we further included a group of GLP-1GIP-treated mice that were additionally food-restricted to match the body weight of the GLP-1GIPLani-treated mice

ISBN 978-0-7817-4380-8.

However, the clinical data suggests that the combined effect of all three receptor targets results in improved overall glycaemic control, with the GLP-1 and GIP effects appearing to counterbalance any blood sugar raising tendency from the glucagon component