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When to seek medical advice Get professional support if you: Feel persistently emotionally numb or disconnected Experience thoughts of hopelessness, self-harm, or suicide Struggle to function at work, school, or in relationships Have a history of depression that seems to be worsening Notice other symptoms like insomnia, changes in appetite, or severe fatigue Your provider may suggest adjusting the dose, slowing titration, or exploring supportive therapy

Bile-stained emesis in an infant requires immediate evaluation as it may be a symptom of intestinal obstruction (malrotation with volvulus, intussusception)

Empty stomach dosing: Oral semaglutide must be taken on an empty stomach with a 30-minute wait before eating, while injectable semaglutide does not have this requirement

One risk that has gained attention with these medications is their possible link to gastroparesis or delayed stomach emptying