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However, a retrospective cohort study published in Diabetes Care did find that use of GLP-1 medications for 1-3 years was associated with a slightly increased risk of all thyroid cancer (adjusted hazard ratio 1.58) and medullary thyroid cancer specifically (adjusted hazard ratio 1.78)

Do-Dai DD, Ho VB, Rovira MJ, Knight RW, Twomey PA

52 In a phase 1b trial done to evaluate the safety, pharmacokinetics and pharmacodynamics of orforglipron in patients with T2DM, orforglipron resulted in significant reductions in HbA1c, fasting blood glucose and body weight, with an adverse event profile consistent with that of other GLP-1RA