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Tirzepatide may be beneficial for individuals who: have struggled with traditional weight loss methods experience frequent hunger or cravings have insulin resistance want medically supervised weight loss are looking to improve metabolic health want to reduce visceral fat A consultation with a qualified provider can help determine candidacy

These symptoms may indicate complications such as faecal impaction, bowel obstruction, or other serious gastrointestinal conditions requiring investigation

Monitoring and follow-up: NICE guideline NG28 recommends regular review of patients on GLP-1 receptor agonists, including assessment of glycaemic control, weight, renal function, and tolerability

A systematic review of the antidepressant effects of glucagon-like peptide 1 (GLP-1) functional agonists: further link between metabolism and psychopathology: special section on translational and neuroscience studies in affective disorders