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Shanghai, China), SOD, and CAT (Sunred Bio, Cat
KMT2A-rarranged leukemias are more dependent on S-adenosylmethionine than non-KMT2A-rearranged leukemias To pinpoint key metabolites driving this differential sensitivity, we focused on the one-carbon cycle, a metabolic network driven by folate and methionine
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This finding indicates that in the minimal in vitro reconstitution system the two sites act cooperatively rather than independently: loss of one site compromises the ability of the other to promote activation
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