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HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma
In estrogen receptor-positive breast cancer, XBP1s directly regulates the transcription of nuclear receptor coactivator 3 (NCOA3), linking UPR signaling to hormone receptor activity and therapy resistance
NFS1 degrades cysteine and releases sulphide, which can be used to generate ironsulphur (FeS) clusters, 138 versatile co-factors that carry out electron transfer, catalysis and afford structural stability
After the sequencing of the human genome, in the early 2000s, the Broad Institute launched in 2010 the Connectivity Map, where numerous compounds were analyzed to find out what was their influence on the expression of genes
