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Women's dosing must account for hormonal status: postmenopausal women lose the estrogen-MOTS-c signaling axis and may benefit from higher-end dosing, while premenopausal women can align timing with luteal-phase insulin resistance
The IL-23/TH17 axis At the center of psoriasis pathology sits the IL-23/TH17 axis
Individuals with less adipose tissue have fewer fat cells available for lipolysis, and the substrate for the enzyme cascade diminishes
Imbalance can manifest as mild GI effects or fatigue patterns in animal models
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