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Because Dihexa is both orally bioavailable and capable of crossing the blood-brain barrier, it can reach the central nervous system through routes that are practical for clinical use

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Notably, MCP-1, also known as chemokine ligand 2 (CCL2), plays a pivotal role in promoting BBB instability by facilitating the recruitment of monocytes/Ms into CNS compartment and contributing to the reorganization of TJ and the actin cytoskeleton (Stamatovic et al., 2003)

The AAY linker was employed between CTL epitopes to facilitate proteasomal cleavage and efficient MHC class I presentation, while the GPGPG linker was used between HTL epitopes to preserve epitope integrity and promote effective MHC class II processing