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Elucidating these mechanisms not only enhances the prediction of endocrine therapy response but also provides a theoretical foundation for the development of next-generation targeted and combination therapies

Rather than acting through conventional receptor-ligand paradigms alone, this peptide is thought to operate at a more nuanced level, potentially interacting with gene expression systems and intracellular regulatory pathways

GHK-Cu contributes ECM-remodeling, collagen and glycosaminoglycan synthesis, and broad gene-expression modulation through copper-mediated signaling