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AML-250 Mitochondrial Respiration Regulates GPX4 Inhibition-Induced Ferroptosis in Acute Myeloid Leukemia

Here, we have utilized liver-specific overexpression of cation transport regulator homolog 1 (Chac1), a recently identified intracellular GSH-degrading enzyme, to induce hepatic GSH depletion during MASLD progression

But with so many options out there, knowing how to get the most out of this powerful antioxidant can feel a little overwhelming

The approval is backed by data from Part 1 of the Phase III RUBY trial, where treatment with the Jemperli regimen led to a 31% reduction in risk of death compared to chemotherapy alone