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The standard NHS regimen for treating deficiency involves loading doses followed by maintenance therapy, with frequency determined by the underlying cause and severity of deficiency
The multifaceted mechanism of action of 5FU involves direct incorporation of its metabolites into DNA (FdUTP) and RNA (FUTP), as well as inhibition of thymidylate synthase (TS) via FdUMP 4,5 , making it more difficult to identify rational combination partners that would enhance clinical responses without eliciting adverse systemic toxicity
To date, we have learned that tirzepatide mainly stimulates insulin secretion through GIP receptor in human islets [149]
C.GuiramandJ.et al (2017)
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