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In December 2025, the TRIUMPH-4 trial reported that retatrutide 12 mg achieved a remarkable 28.7% mean weight loss at 68 weeks in patients with obesity and knee osteoarthritis, with substantial pain relief as well ( [71] )
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Overall, both classes are indifferently recommended by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) as first-line therapy in patients with T2DM and established ASCVD or multiple ASCVD risk factors to reduce the risk of major adverse cardiovascular events (MACE), such as myocardial infarction, stroke, and cardiovascular death [6, 7]
AB 1990 is most relevant to weight-loss service models that involve compounded medications, third-party pharmacy relationships, or advertising that compares compounded products to branded GLP-1 drugs
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