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Longer-term continuous use (6+ months) has less established safety data, though no significant concerns have emerged
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By competitively binding to p53, FOXO4-DRI displaces endogenous FOXO4, causing p53 nuclear exclusion and translocation to mitochondria where it triggers the intrinsic apoptotic pathway through caspase-3/7 activation
Protocol examples and practical schedules Translating the above information into concrete protocols helps researchers plan their approach systematically
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