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10.1371/journal.pone.0061315 38 ParkJ.LeeH.KimS.YangS

In a study of cancer patients taking high dose acetaminophen (an average dose of 400 mg/kg/day, up to a maximum of 1 gram/kg/day), a rescue dose of NAC within 8 hours of acetaminophen dosing prevented severe liver toxicity (Kobrinsky 1996)

However, this review also noted that the quality of the studies was not very high, so more studies are needed before its possible to make any firm recommendations