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Mild allergic symptoms may include: Skin reactions at the injection site or elsewhere on the body, such as hives (urticaria), itching, or a raised rash Generalised itching without an obvious rash Serious allergic symptoms requiring urgent medical attention include: Swelling of the face, lips, tongue, or throat (angioedema) Respiratory symptoms such as wheezing, shortness of breath, or a tight chest Difficulty breathing or swallowing A sudden drop in blood pressure, leading to dizziness or fainting Rapid or weak pulse Widespread rash or hives Nausea, vomiting, or abdominal cramping in conjunction with other allergic symptoms Severe allergic reactions (anaphylaxis) are rare but represent a medical emergency requiring immediate treatment

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RIF is a central pathological hallmark of end-stage renal disease (ESRD) arising from various CKD and is closely associated with diminished renal function and patient prognosis