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Description

Tirzepatide activates both GLP-1 and GIP receptors, offering dual-pathway appetite suppression that may exceed single-agent semaglutide for weight maintenance

By d 56, neither group was significantly improved compared with baseline (ARA 290 = 1.8 2.3 and placebo = 3.1 2.2)

Higher doses reached that plateau later in the trial. In a 112-week step-down trial, participants maintained 21.9% loss on the top dose, 16.6% after stepping down to 5 mg, and 9.9% on placebo