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The isolated complex is bivalent to the IgG target, with a single FcR fragment featuring both N- and C-termini binding the Fc in a 2:1 manner
Pretorius E
I n skeletal muscle, IGF1R activation sensitizes IRS1 to degradation, and a screen for the responsible E3 ligase identified Fbxo40 as mediating this rapid turnover of IRS1, since IRS1 loss can be rescued by knockdown of Fbxo40
Diagnosis of isovaleric acidaemia by tandem mass spectrometry: false positive result due to pivaloylcarnitine in a newborn screening programme
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