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Exposure of endothelial cells in culture to oxidized low-density lipoprotein, an established inducer of cellular senescence [104] , results in an upregulation of MERCs [105]
Osteoarthritis Cartilage
The key mechanistic evidence: pre-treatment with L-NAME (N-Nitro-L-arginine methyl ester, a non-selective NOS inhibitor) or L-NMMA (a selective eNOS inhibitor) abolishes BPC-157s angiogenic effect in wound models CD31+ microvessel density in BPC-157 + L-NAME groups returns to vehicle-equivalent levels
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