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Although, the mucosal GSH levels achieved after NAC administration are still below control values, these findings suggest the existence of a critical threshold level of mucosal GSH that confers cytoprotection
This work was funded by the National Heart, Lung and Blood Institute (R01HL095388 to AS and MEL), National Center for Advancing Translational Science (UL1 TR000157 to AS and MEL), National Science Foundation (Integrative Graduate Education and Research Traineeship to JDC and JEZ), British Columbia Lung Association, Canadian Institute for Health Research, Parker B Francis Foundation (Senior Fellowship to TLH) and the Dutch Asthma Foundation and European Respiratory Society (International Research Fellowship to CAB)
Using this same approach to examine the cytotoxic effects of PE treatment (Zhang et al., 2021), a 50 M PE dose was selected for subsequent experimental use (Figures 3C,D)
Consistently, elevated circulating IL-6 levels are associated with increased mortality risk and greater motor symptom severity in PD, reflecting a sustained TNF--driven inflammatory state [188]
