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IR can induce ferroptosis in intestinal tissue by increasing ACSL4 expression [39], decreasing GPX4 expression and activity [39, 44] and manipulating iron homeostasis to a pro-ferroptotic state [44, 52]
Metabolic reprogramming for cancer cells and their microenvironment: beyond the Warburg effect
While adequate folate intake appears protective before malignant change occurs, excessive folic acid exposure, particularly in susceptible individuals with reduced DHFR activity, may not always be desirable
If you identify with any of these symptoms, reaching out to a healthcare professional could be a smart move
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