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Overall, theoretically, differences in the pharmacokinetic profiles of different GLP-1RAs may have important implications for their efficacy in BAD and perhaps help explain why liraglutide could be superior in reducing symptoms of BAD as compared with the more potent and longer-acting semaglutide

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Finally, 7 pathways grouped within the biosynthesis class were also significantly less abundant with an increase in NR, which were (I) the diacylglycerol biosynthesis III pathway, (II) and (III) the NAD salvage pathways I and V (PNC IV and V cycles), (IV) and (V) the phosphatidylglycerol biosynthesis I and II (plastidic non plastidic) pathways, (VI) the isoprene biosynthesis I pathway and (VII) the methylerythritol phosphate pathway II

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