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Typically, those who should avoid GLP-1s are those with: A personal or family history of certain thyroid cancers Multiple endocrine neoplasia syndrome type 2 A history of pancreatitis Severe gastroparesis (delayed stomach emptying) Pregnancy or plans to become pregnant Additionally, if you have a history of eating disorders, severe depression or unrealistic weight loss expectations, its important to address these concerns with your physician before considering medication

Are these just anecdotes, or is there data behind them

Every dilution you make from that point depends on getting this starting figure right

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