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An aminoisobutyric acid (Aib) substitution at position 8 protects against degradation by dipeptidyl peptidase-4 (DPP-4), while attachment of a C18 fatty diacid chain via a -glutamic acid spacer promotes strong binding to serum albumin
went all out the window
No published human efficacy trials for GH deficiency, body composition, or anti-aging applications exist
however, if not adequately controlled, it could further aggravate glucose and lipid metabolism [4]
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