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The bulk of evidence is pre-clinical, concentrated in skin, wound-healing, and hair-follicle research

Injection of CagA into cells through T4SS fimbriae induces cell changes, impairs cell motility, proliferation, apoptosis, and alters cytoskeleton arrangement

In experimental models, OLETF rats have shown local RAS activation, which resulted in oxidative stress and kidney progressive damage, whereas treatment with dapagliflozin remarkably lowered the urinary ANG II and AGT levels (36)