Samples were boiled at 70 C for 10 min, then electrophoresed at ~100 V for ~1.5 h using the NuPAGE electrophoresis system employing a NuPAGE 412% Bis-Tris Gel, 1X NuPAGE MES SDS Running Buffer, and NuPAGE Antioxidant (Thermo, Ref #NP0322, #NP0002, and #NP0005, respectively)
Body Mass Index (BMI) was in the spotlight again for not being a good predictor of illness nor a true predictor of obesity
For patients who want more aggressive results or who have not responded optimally to semaglutide, tirzepatide is a powerful step up
Clinically, MS is characterized by recurrent episodes of neurological dysfunction, including optic neuritis, sensory alterations, motor weakness, gait disturbances, and cognitive impairment