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The second class is inhibitors of the GLP-1 degrading enzyme, dipeptidyl pepitidase IV (Sitagliptin and related drugs) which can be given orally and increase the plasma level of GLP-1 and other peptides degraded by DPP-4
This action causes local Ca 2+ elevations in pericytes, leading to depolarization and reduced CBF [90, 91]
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