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demonstrated the effect of GLP-1 on macrophage activation, which contributed to M2 polarization and secretion of anti-inflammatory factors in RAW 264.7 cells 52

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Due to the advancements of neurological studies, brain function can be evaluated by monitoring dynamic changes of cerebral blood flow according to neurovascular coupling theory, i.e., neurons, astrocyte, and arterial vessel communication 39,40,41

Serum liver tests should be performed prior to therapy and at frequent intervals thereafter, especially during the first six months of valproate therapy