According to the results of the RCT for patients with monogenic obesity ( LEPR or POMC deficiency) and acquired hypothalamic obesity, setmelanotide can reduce body weight and inhibit appetite to a certain extent, and common adverse reactions include injection site reactions, skin hyperpigmentation, nausea, diarrhea, and abdominal pain, with occasional occurrences of sexual adverse reactions, depression, and suicidal ideation [51,52]
For those taking GLP-1 medications, consuming high-quality protein throughout the day, ideally aiming for a practical target of around 25-30g per meal, can help to preserve muscle mass and support overall metabolic health (8)
For this specific variant, temperature increases, such as having a fever, exposure to a sauna, or during heatstroke, can cause the CPT2 enzyme not to function
Cold foods become your best friend because hot food aromas are a major nausea trigger