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2014 paper demonstrating Dihexa's synaptogenic effects through the HGF/c-Met system was retracted in April 2025 (PMID: 40312093)
This was shown to be around 10 times less potent at the human GLP-1R and approximately equivalent potency at GCGR in comparison to the native peptides at eliciting cAMP response in vitro
The route can shift the GI picture (injectable avoids gut-driven complaints) without changing the underlying metabolism
Once other conditions are ruled out, a histamine elimination diet could be started to see if symptoms improve when histamine-rich foods are eliminated from the diet
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