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It remains to be elucidated whether the process of aging is accelerating only on the skin while GLP-1RA is delaying the systemic aging, and if so, which exact pathophysiological mechanisms are hidden behind this complication

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IGF-1 LR3 has been extensively used in muscle satellite cell research, bone biology, neuroprotection models, and metabolic signaling studies as a surrogate for sustained IGF-1 receptor activation

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