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While this helps with appetite changes, it can also trigger nausea via central nervous system pathways, particularly in the early weeks of treatment
These risks have been reported across GLP-1 drugs, including those containing semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound)
however, most phase III clinical studies are of insufficient duration and do not include enough study participants to effectively gauge long-term safety
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