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If tirzepatide reduces your appetite and you find yourself drinking less coffee because you are not eating breakfast, the resulting caffeine withdrawal could trigger migraines

The real question is whether Lilly can keep converting that demand into market-share gains, margin expansion, and confidence in its full-year guidance while Novo Nordisk pushes back with oral Wegovy and a broader obesity franchise

Regulatory Status and FDA Approval Timeline Current FDA Status (as of June 2026) The FDA has not approved retatrutide for any indication as of June 2026

Implementation requires a federal-only mandate covering federally-regulated employers plus provincial coordination