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Less muscle means a slower metabolism, reduced insulin sensitivity, and shifts in body composition and strength that heighten the risk for weight gain, fatigue, and bone loss over time
Rosenstock J, Guerci B, Hanefeld M, et al
Phase 2 trial data (NEJM, 2023) reported a mean body weight reduction of approximately 24% over 48 weeks at the highest dose, though larger Phase 3 trials are needed to confirm these findings
One study compared them directly and found that gastric emptying half-time was delayed by 52 minutes with lixisenatide (short-acting) but only 25 minutes with liraglutide (long-acting) [2]
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