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Food and Drug Administration (FDA) about these findings and recommends that people using these untested products contact their physicians for advice and discussion on alternative treatment options. The Study Identified a Chemical Reaction Between Tirzeptide and Vitamin B12 Lillys laboratory testing found that the interaction between tirzepatide and vitamin B12 produced a molecule larger than tirzepatide alone a change that could theoretically affect how the drug is absorbed, distributed, metabolized, or eliminated in the body, the study authors wrote

It was identified as a primary metabolite of Melanotan II, formed by hydrolytic cleavage of the lactam bridge between Asp and Lys