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Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease
Building on these findings, the investigation was quickly extended to drug-related rewards, and a growing body of preclinical studies across a range of substances suggests that GLP-1 receptor agonists can reduce behavioral patterns associated with addiction
In contrast, treatment effects evaluated by the trial product estimand assumed that patients received the study drug for the duration of the trial and did not receive any additional blood glucose lowering medications (thereby aiming to reflect the effects of the study medications without the confounding effects of rescue medication or any other changes in glucose-lowering medication) [21]
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