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The clinical relevance of the treatment effect estimated using last observation on-treatment carried forward will be limited if trial participants tend to discontinue placebo earlier (or later) than participants in the active treatment group [4] since there is a risk of not comparing like with like in this type of analysis
It remains stable at room temperature in capsule form
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the leading candidate described in the literature is beta-3 adrenergic signaling in adipose tissue, which raises intracellular cyclic AMP, activates hormone-sensitive lipase and initiates triglyceride hydrolysis
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