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The Role of GLP-1 and GLP-1 Agonist in Type 2 Diabetes
One consistent theme across studies is that when patients stop these medications, weight regain is common
It is also known that acetate in the large intestine promotes the secretion of anorectic hormones such as PYY and GLP-1 from large intestinal L cells and leptin from adipocytes via GPR41 and GPR43 expressed in the intestinal epithelium 14
The takeaway from that table is the whole point of an honest comparison: the two rows with real strength each describe only one drug, the direct cagrilintide-vs-retatrutide row is empty, and the only cross-drug row is explicitly weak
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