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In summary, FGF21s anti-inflammatory actions likely arise from both direct suppression of proinflammatory signalling, by innate and possibly adaptive immune cell types as well as attenuation of immune-effector cell infiltration into the liver, and its indirect inhibition of pro-inflammatory signals released by injured hepatocytes
On the 12th day, the G/D-CuP group exhibited significantly fewer blood vessels, while CD31 expression persisted in the M-CuP and G/M-CuP groups
Fasshauer M, Bluher M
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