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Factors that may predispose patients to greater heart rate changes include: Higher doses of semaglutide Rapid dose escalation Significant and rapid weight loss Pre-existing cardiovascular conditions Concurrent medications affecting heart rate Dehydration or electrolyte imbalances According to FDA prescribing information, palpitations have been reported in clinical trials, though precise incidence rates vary by product and study population

Once secreted, it is rapidly degraded by an enzyme called dipeptidyl peptidase-4 (DPP-4)

These associations remain consistent across sensitivity analyses, suggesting that medication choice in obesity management may have implications extending beyond metabolic benefits to include ocular health considerations