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That range frequently provides a good balance of stability, target specificity, and ability to cross cell membranes or bind to receptors

Clinical trials have not consistently shown improvement in cognitive function among older adults with or without dementia when supplemented with vitamin B12 alone or in combination with other B vitamins, even when blood concentrations of homocysteine come down

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[2] Urgent medical attention is required if neurological symptoms develop, as these may indicate subacute combined degeneration of the spinal corda serious complication requiring immediate treatment