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Aspirin (Acetylsalicylic Acid) Mechanism: Irreversibly inhibits COX-1 enzyme thromboxane A inhibits platelet aggregation Indications: Acute coronary syndrome (ACS) Myocardial infarction (primary & secondary prevention) Stroke/TIA prevention Peripheral arterial disease Dose: Low-dose: 75100 mg/day for antiplatelet effect Higher doses: anti-inflammatory (not usually for antiplatelet) Side Effects: Gastrointestinal irritation / bleeding Allergic reactions Rare: Reyes syndrome (in children) Clopidogrel Mechanism: Irreversibly inhibits ADP (P2Y12) receptor on platelets prevents platelet activation and aggregation Indications: ACS (with or without stenting) Post-percutaneous coronary intervention (PCI) with stent Stroke/TIA prevention Peripheral arterial disease Dose: 75 mg orally once daily (after a loading dose in ACS: 300600 mg) Side Effects: Bleeding (less GI irritation than aspirin) Rare: thrombotic thrombocytopenic purpura (TTP) Aspirin vs Clopidogrel: Antiplatelet Mechanisms and Indications Aspirin & Clopidogrel Both aspirin and clopidogrel are antiplatelet drugs used to prevent arterial thrombosis, but they work differently

Nauck MA, Meier JJ (2016) The incretin effect in healthy individuals and those with type 2 diabetes: physiology, pathophysiology, and response to therapeutic interventions

Methods The Peptide Innovation for Early Diabetes Treatment (PIONEER) 12 trial was a randomised, double-dummy, active-controlled, parallel-group, Phase IIIa trial conducted over 26 weeks at 90 sites across the China region (including mainland China, Taiwan and Hong Kong) and five other countries