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NOX4 is known to be activated by the indoxyl sulfate (IS), an aggressive uremic toxin which in turn results in increased ROS formation
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Staying well-hydrated not only alleviates some of the gastrointestinal effects but also supports overall well-being during treatment
More importantly, the magnitude of improvement in body weight resulted from increased energy expenditure and decreased food intake, which led to a remarkable loss of fat mass
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