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Seek immediate medical attention (call 999 or attend A&E) if you develop: Severe, unrelenting abdominal pain Signs of severe dehydration with confusion or altered consciousness Persistent vomiting with inability to retain any fluids for more than 24 hours Chest pain or difficulty breathing alongside gastrointestinal symptoms For patients with diabetes taking GLP-1 medications, persistent vomiting poses additional risks

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If symptoms suddenly return after months of stability, consider whether anything has changed