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Nat Rev Cancer 2, 720

Current clinical evidence supports long-term semaglutide use, with safety data extending to 3+ years in trials

Symptoms that may suggest pancreatic cancer (though often non-specific and appearing late in the disease course) include: Persistent upper abdominal or back pain Unexplained weight loss Jaundice (yellowing of the skin and eyes), which may indicate bile duct obstruction New-onset diabetes or worsening glycaemic control in established diabetes Loss of appetite , nausea, or changes in bowel habit (pale, greasy stools) While these symptoms can have many causes, patients experiencing themparticularly if persistent or progressiveshould contact their GP promptly for assessment