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[3] Maquart FX, Bellon G, Pasco S, Monboisse JC

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And the zonula occludens proteins , ZO-1, ZO-2 and ZO-3, sit on the cytoplasmic face as scaffolds, linking the transmembrane components to the actin cytoskeleton which is how a junction can be actively pulled open rather than merely leaking

You start at the full therapeutic dose from the first injection and maintain it for all 4